Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation

@inproceedings{Ummanni2011UbiquitinCH,
  title={Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylation},
  author={Ramesh Ummanni and Edgar Jost and Melanie Braig and Frithjof Lohmann and Frederike Mundt and Christine Barett and Thorsten Schlomm and Guido Sauter and Tina Senff and C Carsten Bokemeyer and Holger S{\"u}ltmann and Catherine Meyer-Schwesinger and Tim H. Br{\"u}mmendorf and Stefan Balabanov},
  booktitle={Molecular Cancer},
  year={2011}
}
We have previously reported significant downregulation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in prostate cancer (PCa) compared to the surrounding benign tissue. UCHL1 plays an important role in ubiquitin system and different cellular processes such as cell proliferation and differentiation. We now show that the underlying mechanism of UCHL1 downregulation in PCa is linked to its promoter hypermethylation. Furthermore, we present evidences that UCHL1 expression can affect the… CONTINUE READING
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