Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.

@article{Bienko2005UbiquitinbindingDI,
  title={Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.},
  author={Marzena Magda Bienko and Catherine Green and Nicola Crosetto and Fabian Rudolf and Grzegorz Zapart and Barry J. Coull and Patricia L. Kannouche and Gerhard Wider and Matthias Peter and A. R. Lehmann and Kay Hofmann and Ivan Dikic},
  journal={Science},
  year={2005},
  volume={310 5755},
  pages={
          1821-4
        }
}
Translesion synthesis (TLS) is the major pathway by which mammalian cells replicate across DNA lesions. Upon DNA damage, ubiquitination of proliferating cell nuclear antigen (PCNA) induces bypass of the lesion by directing the replication machinery into the TLS pathway. Yet, how this modification is recognized and interpreted in the cell remains unclear. Here we describe the identification of two ubiquitin (Ub)-binding domains (UBM and UBZ), which are evolutionarily conserved in all Y-family… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 290 CITATIONS, ESTIMATED 58% COVERAGE

501 Citations

0204060'00'04'09'14'19
Citations per Year
Semantic Scholar estimates that this publication has 501 citations based on the available data.

See our FAQ for additional information.

Similar Papers

Loading similar papers…