Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes.

@article{Mattera2008UbiquitinBA,
  title={Ubiquitin binding and conjugation regulate the recruitment of Rabex-5 to early endosomes.},
  author={Rafael Mattera and Juan S Bonifacino},
  journal={The EMBO journal},
  year={2008},
  volume={27 19},
  pages={2484-94}
}
Rab GTPases and ubiquitination are critical regulators of transmembrane cargo sorting in endocytic and lysosomal targeting pathways. The endosomal protein Rabex-5 intersects these two layers of regulation by being both a guanine nucleotide exchange factor (GEF) for Rab5 and a substrate for ubiquitin (Ub) binding and conjugation. The ability of trafficking machinery components to bind ubiquitinated proteins is known to have a function in cargo sorting. Here, we demonstrate that Ub binding is… CONTINUE READING

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