Ubiquitin and membrane protein turnover: from cradle to grave.

  title={Ubiquitin and membrane protein turnover: from cradle to grave.},
  author={Jason A MacGurn and Pi-Chiang Hsu and Scott D Emr},
  journal={Annual review of biochemistry},
From the moment of cotranslational insertion into the lipid bilayer of the endoplasmic reticulum (ER), newly synthesized integral membrane proteins are subject to a complex series of sorting, trafficking, quality control, and quality maintenance systems. Many of these processes are intimately controlled by ubiquitination, a posttranslational modification that directs trafficking decisions related to both the biosynthetic delivery of proteins to the plasma membrane (PM) via the secretory pathway… CONTINUE READING


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