Ubiquitin and membrane protein turnover: from cradle to grave.

@article{MacGurn2012UbiquitinAM,
  title={Ubiquitin and membrane protein turnover: from cradle to grave.},
  author={Jason A MacGurn and Pi-Chiang Hsu and Scott D Emr},
  journal={Annual review of biochemistry},
  year={2012},
  volume={81},
  pages={231-59}
}
From the moment of cotranslational insertion into the lipid bilayer of the endoplasmic reticulum (ER), newly synthesized integral membrane proteins are subject to a complex series of sorting, trafficking, quality control, and quality maintenance systems. Many of these processes are intimately controlled by ubiquitination, a posttranslational modification that directs trafficking decisions related to both the biosynthetic delivery of proteins to the plasma membrane (PM) via the secretory pathway… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 101 extracted citations

Similar Papers

Loading similar papers…