Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage.

@article{Moudry2012UbiquitinactivatingEU,
  title={Ubiquitin-activating enzyme UBA1 is required for cellular response to DNA damage.},
  author={Pavel Moudry and Claudia Lukas and Libor Macurek and Hana Hanzlikova and Zdenek Hodny and Jiri Lukas and Jiri Bartek},
  journal={Cell cycle},
  year={2012},
  volume={11 8},
  pages={
          1573-82
        }
}
The cellular DNA damage response (DDR) machinery that maintains genomic integrity and prevents severe pathologies, including cancer, is orchestrated by signaling through protein modifications. Protein ubiquitylation regulates repair of DNA double-strand breaks (DSBs), toxic lesions caused by various metabolic as well as environmental insults such as ionizing radiation (IR). Whereas several components of the DSB-evoked ubiquitylation cascade have been identified, including RNF168 and BRCA1… CONTINUE READING
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