Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family

@inproceedings{Becuwe2012UbiquitinMediatedRO,
  title={Ubiquitin-Mediated Regulation of Endocytosis by Proteins of the Arrestin Family},
  author={Michel Becuwe and Antonio Herrador and Rosine Haguenauer-Tsapis and Olivier Vincent and S{\'e}bastien L{\'e}on},
  booktitle={Biochemistry research international},
  year={2012}
}
In metazoans, proteins of the arrestin family are key players of G-protein-coupled receptors (GPCRS) signaling and trafficking. Following stimulation, activated receptors are phosphorylated, thus allowing the binding of arrestins and hence an "arrest" of receptor signaling. Arrestins act by uncoupling receptors from G proteins and contribute to the recruitment of endocytic proteins, such as clathrin, to direct receptor trafficking into the endocytic pathway. Arrestins also serve as adaptor… CONTINUE READING

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