Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.

@article{Hsia2014UbiquitinEL,
  title={Ubiquitin E3 ligase Nedd4-1 acts as a downstream target of PI3K/PTEN-mTORC1 signaling to promote neurite growth.},
  author={Hung-En Hsia and R. Ram Kumar and Rossella Luc{\`a} and Michiko Takeda and Julien Courchet and Jonathan Nakashima and Shumin Wu and Sandra Goebbels and Wenlin An and Britta Johanna Eickholt and Franck Polleux and Daniela Rotin and Hong Wu and Moritz J Rossner and Claudia Bagni and J. -S. Rhee and Nils Brose and Hiroshi Kawabe},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 36},
  pages={
          13205-10
        }
}
Protein ubiquitination is a core regulatory determinant of neural development. Previous studies have indicated that the Nedd4-family E3 ubiquitin ligases Nedd4-1 and Nedd4-2 may ubiquitinate phosphatase and tensin homolog (PTEN) and thereby regulate axonal growth in neurons. Using conditional knockout mice, we show here that Nedd4-1 and Nedd4-2 are indeed required for axonal growth in murine central nervous system neurons. However, in contrast to previously published data, we demonstrate that… CONTINUE READING

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  • 2018
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

A unifying model for mTORC1-mediated regulation of mRNA translation

CC Thoreen
  • Nature
  • 2012
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

The functions and regulation of the PTEN tumour suppressor

  • Nature Reviews Molecular Cell Biology
  • 2012
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

Functional interaction of phosphatase and tensin homologue (PTEN) with the E3 ligase NEDD4-1 during neuronal response to zinc

Kwak Y-D
  • J Biol Chem 285(13):9847–9857
  • 2010
VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL

NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN

Xinjiang Wang, Lloyd C Trotman, +9 authors Xuejun Jiang
  • Cell
  • 2007
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Control of dendritic arborization by the phosphoinositide-3'-kinase-Akt-mammalian target of rapamycin pathway.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 2005
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL