Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response

@article{Kim2007UbiquitinBindingPR,
  title={Ubiquitin-Binding Protein RAP80 Mediates BRCA1-Dependent DNA Damage Response},
  author={Hongtae Kim and Junjie Chen and Xiaochun Yu},
  journal={Science},
  year={2007},
  volume={316},
  pages={1202 - 1205}
}
Mutations in the breast cancer susceptibility gene 1 (BRCA1) are associated with an increased risk of breast and ovarian cancers. BRCA1 participates in the cellular DNA damage response. We report the identification of receptor-associated protein 80 (RAP80) as a BRCA1-interacting protein in humans. RAP80 contains a tandem ubiquitin-interacting motif domain, which is required for its binding with ubiquitin in vitro and its damage-induced foci formation in vivo. Moreover, RAP80 specifically… 

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