Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization

@inproceedings{Cai2010UbiquitinSUMOMR,
  title={Ubiquitin/SUMO Modification Regulates VHL Protein Stability and Nucleocytoplasmic Localization},
  author={Qiliang Cai and Erle S Robertson},
  booktitle={PloS one},
  year={2010}
}
Functional inactivation of the von Hippel-Lindau (VHL) tumor suppressor protein is linked to the development of several forms of cancer as well as oncogenic progression like sporadic renal clear-cell carcinomas (RCC). Despite the critical role played by VHL in destruction of hypoxia-inducible factor α (HIFα) via ubiquitin-mediated proteolysis, very little is known about the post-translational modification which regulates VHL activity. Our previous study showed that the SUMO E3 ligase PIASy… CONTINUE READING

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Regulation of ubiquitin ligase dynamics by the nucleolus

The Journal of cell biology • 2005
View 6 Excerpts
Highly Influenced

Function and regulation of cullin–RING ubiquitin ligases

Nature Reviews Molecular Cell Biology • 2005
View 3 Excerpts
Highly Influenced

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