Ubiquinone-10 content in lymphocytes of phenylketonuric patients.

  title={Ubiquinone-10 content in lymphocytes of phenylketonuric patients.},
  author={Catrina Colom{\'e} and Rafael Artuch and Mar{\'i}a Ant{\`o}nia Vilaseca and Cristina Sierra and N{\'u}ria Brandi and Francisco Jos{\'e} Cambra and Nilo Lambruschini and Jaume Campistol},
  journal={Clinical biochemistry},
  volume={35 1},
OBJECTIVES To investigate the ubiquinone-10 content in lymphocytes from phenylketonuric patients. DESIGN AND METHODS We compared 23 patients with 25 age-matched controls. Ubiquinone-10 was analyzed by HPLC with electrochemical detection. RESULTS Ubiquinone-10 concentrations were significantly lower in patients (77-270 nmol/g of protein) compared with controls (190-550) (p < 0.001). Significantly negative correlation was observed between ubiquinone-10 and phenylalanine (r = -0.441; p < 0.05… CONTINUE READING

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