Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex

@inproceedings{Ricketts2015Ubinuclein1CH,
  title={Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex},
  author={M Daniel Ricketts and Brian G. Frederick and Henry Hoff and Yong Tang and David C. Schultz and Taranjit Singh Rai and Maria Grazia Vizioli and Peter David Adams and Ronen Marmorstein},
  booktitle={Nature communications},
  year={2015}
}
Histone chaperones bind specific histones to mediate their storage, eviction or deposition from/or into chromatin. The HIRA histone chaperone complex, composed of HIRA, ubinuclein-1 (UBN1) and CABIN1, cooperates with the histone chaperone ASF1a to mediate H3.3-specific binding and chromatin deposition. Here we demonstrate that the conserved UBN1 Hpc2-related domain (HRD) is a novel H3.3-specific-binding domain. Biochemical and biophysical studies show the UBN1-HRD preferentially binds H3.3/H4… CONTINUE READING
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