Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: implications for p53 ubiquitination.

@article{ReyesHernndez2010Ube2l3GE,
  title={Ube2l3 gene expression is modulated by activation of the aryl hydrocarbon receptor: implications for p53 ubiquitination.},
  author={Octavio D. Reyes-Hern{\'a}ndez and Alejandro Mej{\'i}a-Garc{\'i}a and Esmeralda M Sanchez-Ocampo and Mar{\'i}a Asunci{\'o}n Caba{\~n}as-Cort{\'e}s and Pablo Ram{\'i}rez and Lorena Ch{\'a}vez-Gonz{\'a}lez and Frank J. Gonzalez and Guillermo Elizondo},
  journal={Biochemical pharmacology},
  year={2010},
  volume={80 6},
  pages={932-40}
}
Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a halogenated aromatic hydrocarbon and environmental contaminant, results in several deleterious effects, including fetal malformation and cancer. These effects are mediated by the aryl hydrocarbon receptor (AhR), a ligand-activated receptor that regulates the expression of genes encoding xenobiotic-metabolizing enzymes. Several reports suggest that AhR function is beyond the adaptive chemical response. In the present study, we analyzed… CONTINUE READING

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