Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells

@inproceedings{Chang2012Ubc13MT,
  title={Ubc13 maintains the suppressive function of regulatory T cells and prevents their conversion into effector-like T cells},
  author={Jae-Hoon Chang and Yichuan Xiao and Hongbo Hu and Jin Jin and Jiayi Yu and Xiaofei Zhou and Xuefeng Wu and Howard M Johnson and Shizuo Akira and Manolis Pasparakis and Xuhong Cheng and Shao-Cong Sun},
  booktitle={Nature Immunology},
  year={2012}
}
The maintenance of immune homeostasis requires regulatory T cells (Treg cells). Here we found that Treg cell–specific ablation of Ubc13, a Lys63 (K63)-specific ubiquitin-conjugating enzyme, caused aberrant T cell activation and autoimmunity. Although Ubc13 deficiency did not affect the survival of Treg cells or expression of the transcription factor Foxp3, it impaired the in vivo suppressive function of Treg cells and rendered them sensitive to the acquisition of T helper type 1 (TH1) cell– and… CONTINUE READING
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