Ubc13: the Lys63 ubiquitin chain building machine

  title={Ubc13: the Lys63 ubiquitin chain building machine},
  author={Curtis D Hodge and Leo Spyracopoulos and J N Mark Glover},
Ubc13 is an ubiquitin E2 conjugating enzyme that participates with many different E3 ligases to form lysine 63-linked (Lys63) ubiquitin chains that are critical to signaling in inflammatory and DNA damage response pathways. Recent studies have suggested Ubc13 as a potential therapeutic target for intervention in various human diseases including several different cancers, alleviation of anti-cancer drug resistance, chronic inflammation, and viral infections. Understanding a potential therapeutic… CONTINUE READING

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