UVM, an ultraviolet-inducible RecA-independent mutagenic phenomenon in Escherichia coli.

  title={UVM, an ultraviolet-inducible RecA-independent mutagenic phenomenon in Escherichia coli.},
  author={Vaseem A Palejwala and Gagan A. Pandya and Opinder S. Bhanot and Jerome J. Solomon and Hedwig S. Murphy and Paul M. Dunman and M Zafri Humayun},
  journal={The Journal of biological chemistry},
  volume={269 44},
Most mutagenic DNA lesions are noninstructive in the sense that template instruction is either missing or inaccessible during DNA replication, leading to replication arrest. According to the SOS hypothesis, arrested replication induces the expression of SOS factors that force replication past stalled sites at the cost of mutagenesis. We have recently shown that prior UV irradiation of delta recA cells, in which the SOS pathway does not function, enhances mutagenesis at an ethenocytosine residue… CONTINUE READING
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