UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system.

@article{Zhang2008UVBRI,
  title={UVB radiation-mediated inhibition of contact hypersensitivity reactions is dependent on the platelet-activating factor system.},
  author={Qiwei Zhang and Yongxue Yao and Raymond L. Konger and Anthony L. Sinn and Shanbao Cai and Karen E. Pollok and Jeffrey B Travers},
  journal={The Journal of investigative dermatology},
  year={2008},
  volume={128 7},
  pages={1780-7}
}
Through its ability to both induce immunosuppression and act as a carcinogen, UVB radiation plays a major role in cutaneous malignancies. Recent studies have indicated that UVB-mediated inhibition of delayed-type hypersensitivity reactions is mediated, in part, by the lipid mediator platelet-activating factor (PAF). The objective of this study was to further define the mechanism by which UVB inhibits contact hypersensitivity (CHS) reactions. UVB irradiation resulted in an inhibition of… CONTINUE READING

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