UVB irradiation-induced apoptosis increased in lymphocytes of Huntington's disease patients.

@article{Jakab2001UVBIA,
  title={UVB irradiation-induced apoptosis increased in lymphocytes of Huntington's disease patients.},
  author={Katalin Tauber Jakab and Zdenek Novak and J{\'o}zsef I. Engelhardt and Lajos Kem{\'e}ny and J{\'a}nos K{\'a}lm{\'a}n and L{\'a}szl{\'o} V{\'e}csei and Istv{\'a}n Rask{\'o}},
  journal={Neuroreport},
  year={2001},
  volume={12 8},
  pages={1653-6}
}
Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder caused by CAG repeat expansion in the IT-15 gene coding for huntingtin. The mechanism of neuronal degeneration induced by the mutant huntingtin is not known. Apoptosis may play a role in it. Huntingtin is widely expressed in the cells, so abnormalities can be expected also in non-neural tissue. We examined the susceptibility of lymphocytes from HD patients, asymptomatic carriers and normal individuals to UVB… CONTINUE READING