UVB-irradiated dendritic cells induce nonproliferating, regulatory type T cells.

  title={UVB-irradiated dendritic cells induce nonproliferating, regulatory type T cells.},
  author={J C Simon and Hiromitsu Hara and Ralf W Denfeld and Sophie G. Martin},
  journal={Skin pharmacology and applied skin physiology},
  volume={15 5},
It is well established that low-dose UVB radiation inhibits the antigen-presenting cell (APC) function of murine Langerhans cells in vivo and converts them from immunogenic to tolerogenic APC. Recently, we have shown that UVB-irradiated murine bone marrow-derived dendritic cells (UVB-DC) suppressed proliferation of naive and primed T cells, but tolerized primed T cells only. To examine the underlying mechanism for these differences, naive OVA(323-339)-peptide-specific, TCR-transgenic T cells… CONTINUE READING
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