UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways.

@article{Nicol2001UVBinducedAO,
  title={UVB-induced apoptosis of human dendritic cells: contribution by caspase-dependent and caspase-independent pathways.},
  author={Chiara Nicol{\'o} and Barbara Tomassini and Maria Rita Rippo and Roberto Testi},
  journal={Blood},
  year={2001},
  volume={97 6},
  pages={1803-8}
}
Dendritic cells (DCs) play a central role in the initiation and regulation of the immune response. The modalities by which DCs are committed to undergo apoptosis are poorly defined. Here it is shown that, unlike death receptor ligands, UVB radiation triggers apoptosis of human DCs very efficiently. UVB exposure is followed by the activation of caspases 8, 9, and 3, by the loss of mitochondrial transmembrane potential (deltaPsim), and by cellular and nuclear fragmentation. Caspase inhibitors… CONTINUE READING

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