UVB-activated psoralen reduces luminal narrowing after balloon dilation because of inhibition of constrictive remodeling.

@article{Perre2002UVBactivatedPR,
  title={UVB-activated psoralen reduces luminal narrowing after balloon dilation because of inhibition of constrictive remodeling.},
  author={Jop Perr{\'e}e and Ton G van Leeuwen and Evelyn Velema and Mirjam B. Smeets and Dominique Paschalis Victor de Kleijn and Cornelius Borst},
  journal={Photochemistry and photobiology},
  year={2002},
  volume={75 1},
  pages={68-75}
}
In this study we have explored the potential of PUVB (8-MOP + UVB) therapy for the reduction of luminal narrowing after arterial injury. In 15 rabbits, balloon dilation of iliac arteries was performed. In 20 arteries, dilation was combined with the delivery of pulsed ultraviolet light B (UVB) irradiation with 10 arteries being previously subjected to sensitizer infusion. Changes in vessel diameter, proliferation and extracellular matrix protein content at 6 weeks were evaluated by means of… CONTINUE READING

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In the irradiation groups , LL was independent of acute gain ( AG ) , as opposed to the control .
In the irradiation groups , LL was independent of acute gain ( AG ) , as opposed to the control .
Collagen content increased significantly after PUVB in media and adventitia , without increased cellular proliferation in all vessel layers .
Collagen content increased significantly after PUVB in media and adventitia , without increased cellular proliferation in all vessel layers .
In 20 arteries , dilation was combined with the delivery of pulsed ultraviolet light B ( UVB ) irradiation with 10 arteries being previously subjected to sensitizer infusion .
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