UVB-Induced p21 degradation promotes apoptosis of human keratinocytes.

  title={UVB-Induced p21 degradation promotes apoptosis of human keratinocytes.},
  author={Xia Lei and Bo Liu and Weinong Han and Mei Ming and Yu-Ying He},
  journal={Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  volume={9 12},
Skin cancer is the most common cancer in the United States. Ultraviolet B (UVB) radiation in sunlight is the major environmental factor causing skin cancer. p21, a p53-inducible protein, plays an important role in cell cycle, DNA repair, and apoptosis. Here we have investigated the effect of UVB radiation on p21 and its molecular mechanisms and function in human HaCaT keratinocytes, which we used as a premalignant cellular model because normal skin harbors numerous clones of p53-mutated… CONTINUE READING


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