UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages

@inproceedings{Greinert2012UVAinducedDD,
  title={UVA-induced DNA double-strand breaks result from the repair of clustered oxidative DNA damages},
  author={Robin Greinert and Bart Volkmer and S. Henning and Eckhardt W Breitbart and Kornelia Greulich and Maria Cristina Cardoso and Alexander Rapp},
  booktitle={Nucleic acids research},
  year={2012}
}
UVA (320-400 nm) represents the main spectral component of solar UV radiation, induces pre-mutagenic DNA lesions and is classified as Class I carcinogen. Recently, discussion arose whether UVA induces DNA double-strand breaks (dsbs). Only few reports link the induction of dsbs to UVA exposure and the underlying mechanisms are poorly understood. Using the Comet-assay and γH2AX as markers for dsb formation, we demonstrate the dose-dependent dsb induction by UVA in G(1)-synchronized human… CONTINUE READING

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