UVA exposure of human skin reconstructed in vitro induces apoptosis of dermal fibroblasts: subsequent connective tissue repair and implications in photoaging

@article{Bernerd1998UVAEO,
  title={UVA exposure of human skin reconstructed in vitro induces apoptosis of dermal fibroblasts: subsequent connective tissue repair and implications in photoaging},
  author={Françoise Bernerd and Daniel Asselineau},
  journal={Cell Death and Differentiation},
  year={1998},
  volume={5},
  pages={792-802}
}
The skin reconstructed in vitro has been previously shown to be a useful model to investigate the effects of UVB exposure (). The present study describes the response to UVA irradiation. Major alterations were observed within the dermal compartment. Apoptosis of fibroblasts located in the superficial area of the dermal equivalent was observed as soon as 6 h after irradiation, leading to their disappearance after 48 h. This effect was obtained without major alterations of epidermal keratinocytes… CONTINUE READING

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