UVA/B-induced apoptosis in human melanocytes involves translocation of cathepsins and Bcl-2 family members.

@article{Bivik2006UVABinducedAI,
  title={UVA/B-induced apoptosis in human melanocytes involves translocation of cathepsins and Bcl-2 family members.},
  author={Cecilia A Bivik and Petra K Larsson and Katarina M K{\aa}gedal and Inger K Rosdahl and Karin M Ollinger},
  journal={The Journal of investigative dermatology},
  year={2006},
  volume={126 5},
  pages={1119-27}
}
We demonstrate UVA/B to induce apoptosis in human melanocytes through the mitochondrial pathway, displaying cytochrome c release, caspase-3 activation, and fragmentation of nuclei. The outcome of a death signal depends on the balance between positive and negative apoptotic regulators, such as members of the Bcl-2 protein family. Apoptotic melanocytes, containing fragmented nucleus, show translocation of the proapoptotic proteins Bax and Bid from the cytosol to punctate mitochondrial-like… CONTINUE READING

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