UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.

@article{Brunner2013UVtriggeredAC,
  title={UV-triggered affinity capture identifies interactions between the Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) and antimalarial agents in live parasitized cells.},
  author={Ralf Brunner and Caroline L Ng and Hamed Aissaoui and Myles H. Akabas and Christoph Boss and Reto Brun and Paul S. Callaghan and Olivier Corminboeuf and David A. Fidock and Ithiel J Frame and Bibia Heidmann and Am{\'e}lie Le Bihan and Paul Jenoe and Corinna Mattheis and Suzette Moes and Ingrid B. M{\"u}ller and Michelle F. Paguio and Paul D Roepe and Romain Siegrist and Till S Voss and Richard Welford and Sergio Wittlin and Christoph Binkert},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 31},
  pages={22576-83}
}
A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reactive affinity capture method to find parasite proteins specifically interacting with the capture compound in living parasitized cells. The capture reagent retained the antimalarial properties of the parent molecule (ACT-213615) and accumulated within parasites. We identified several proteins… CONTINUE READING
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