UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer.

@article{Brash1988UVMP,
  title={UV mutagenic photoproducts in Escherichia coli and human cells: a molecular genetics perspective on human skin cancer.},
  author={Douglas E. Brash},
  journal={Photochemistry and photobiology},
  year={1988},
  volume={48 1},
  pages={
          59-66
        }
}
Abstract— The relevance of photoproducts produced by 254 nm irradiation to human skin cancer is first critically evaluated. Experiments identifying the mutagenic photoproducts at 254 nm are then described. Mutations are primarily due to the(6–4) photoproduct and the cyclobutane pyrimidine dimer, both in E. coli and in human cells. The(6–4) photoproduct may be more important in E. coli and the cyclobutane dimer more important in mammalian cells. In human cells, mutations occur at the C of a TC… CONTINUE READING
BETA

Similar Papers

Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 42 CITATIONS

Genetic Instability and Tumorigenesis

  • Current Topics in Microbiology and Immunology
  • 1997
VIEW 10 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED