UV-induced reactive oxygen species in photocarcinogenesis and photoaging.

  title={UV-induced reactive oxygen species in photocarcinogenesis and photoaging.},
  author={Karin Scharffetter-Kochanek and Meinhard Wlaschek and Peter Brenneisen and Matthias Schauen and Ralf Blaudschun and Jutta Wenk},
  journal={Biological chemistry},
  volume={378 11},
The increase in UV irradiation on earth due to the stratospheric ozone depletion represents a major environmental threat to the skin increasing its risk of photooxidative damage by UV-induced reactive oxygen species (ROS). Increased ROS load has been implicated in several pathological states including photoaging and photocarcinogenesis of the skin. Large efforts have been made to better define the involvement of distinct ROS in photocarcinogenesis and photoaging. Both pathological processes… CONTINUE READING

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