UV-induced immunosuppression in the balance.

  title={UV-induced immunosuppression in the balance.},
  author={Frank R de Gruijl},
  journal={Photochemistry and photobiology},
  volume={84 1},
Around 1980, experiments with hairless mice showed us that UV-induced actinic keratoses (AK) and ensuing skin carcinomas did not arise independently: the rate of occurrence in one skin area was increased considerably if AKs had already been induced separately in another distant skin area, i.e. a systemic effect. The ground laying work of Margaret Kripke in the 1970s provided a fitting explanation: UV-induced immunosuppression and tolerance toward the UV-induced tumors. From Kripke's work a new… CONTINUE READING