UV-induced DNA damage and repair: a review.

  title={UV-induced DNA damage and repair: a review.},
  author={Rajeshwar Prasad Sinha and Donat-P. H{\"a}der},
  journal={Photochemical \& photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology},
  volume={1 4},
  • R. Sinha, D. Häder
  • Published 10 April 2002
  • Biology
  • Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology
Increases in ultraviolet radiation at the Earth's surface due to the depletion of the stratospheric ozone layer have recently fuelled interest in the mechanisms of various effects it might have on organisms. DNA is certainly one of the key targets for UV-induced damage in a variety of organisms ranging from bacteria to humans. UV radiation induces two of the most abundant mutagenic and cytotoxic DNA lesions such as cyclobutane-pyrimidine dimers (CPDs) and 6-4 photoproducts (6-4PPs) and their… 

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