UV filter instability: consequences for the human lens.

  title={UV filter instability: consequences for the human lens.},
  author={Lisa M Taylor and J Andrew Aquilina and Joanne F Jamie and Roger John Willis Truscott},
  journal={Experimental eye research},
  volume={75 2},
Human lenses appear to become coloured with age primarily due to the covalent binding of UV filter compounds to lens proteins. These crystallin modifications result from the inherent instability of the kynurenine UV filters. Here we investigate this decomposition, the role this may have in the formation of other primate UV filters, and the interaction of the intermediates (alpha,beta-ketoalkenes) with lens components. The UV filters kynurenine, 3-hydroxykynurenine and 3-hydroxykynurenine… CONTINUE READING