UV damage-induced RNA polymerase II stalling stimulates H2B deubiquitylation.

@article{Mao2014UVDR,
  title={UV damage-induced RNA polymerase II stalling stimulates H2B deubiquitylation.},
  author={Peng Mao and Rithy Meas and Kathleen M. Dorgan and Michael J. Smerdon},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2014},
  volume={111 35},
  pages={12811-6}
}
Histone H2B monoubiquitylation plays an important role in RNA polymerase II (RNAPII) elongation. Whether this modification responds to RNAPII stalling is not yet known. We report that both yeast and human cells undergo a rapid and significant H2B deubiquitylation after exposure to UV irradiation. This deubiquitylation occurs concurrently with UV-induced transcription arrest and is significantly reduced in a DNA damage-bypassing RNAPII yeast mutant. Consistent with these results, yeast… CONTINUE READING
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