UV damage, DNA repair and skin carcinogenesis.

@article{Cleaver2002UVDD,
  title={UV damage, DNA repair and skin carcinogenesis.},
  author={James E. Cleaver and Eileen Crowley},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2002},
  volume={7},
  pages={
          d1024-43
        }
}
  • J. Cleaver, E. Crowley
  • Published 2002
  • Biology, Medicine
  • Frontiers in bioscience : a journal and virtual library
Skin cancer is unique among human cancers in its etiology, accessibility and the volume of detailed knowledge now assembled concerning its molecular mechanisms of origin. The major carcinogenic agent for most skin cancers is well established as solar ultraviolet light. This is absorbed in DNA with the formation of UV-specific dipyrimidine photoproducts. These can be repaired by nucleotide excision repair or replicated by low fidelity class Y polymerases. Insufficient repair followed by errors… Expand
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The DNA damage response restores DNA integrity and protects against genomic instability that can lead to cancer. The human disease xeroderma pigmentosum (XP) is a prime example of disorders affectingExpand
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TLDR
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TLDR
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BACKGROUND UV radiation can produce mutations in skin cells and correlates strongly with the onset of actinic keratoses and basal and squamous cell carcinomas. Xeroderma pigmentosum (XP) is aExpand
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  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
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