UV damage, DNA repair and skin carcinogenesis.

  title={UV damage, DNA repair and skin carcinogenesis.},
  author={James E. Cleaver and Eileen Crowley},
  journal={Frontiers in bioscience : a journal and virtual library},
  • J. Cleaver, E. Crowley
  • Published 1 April 2002
  • Medicine, Biology
  • Frontiers in bioscience : a journal and virtual library
Skin cancer is unique among human cancers in its etiology, accessibility and the volume of detailed knowledge now assembled concerning its molecular mechanisms of origin. The major carcinogenic agent for most skin cancers is well established as solar ultraviolet light. This is absorbed in DNA with the formation of UV-specific dipyrimidine photoproducts. These can be repaired by nucleotide excision repair or replicated by low fidelity class Y polymerases. Insufficient repair followed by errors… 

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