UV as an amplifier rather than inducer of NF-kappaB activity.

@article{ODea2008UVAA,
  title={UV as an amplifier rather than inducer of NF-kappaB activity.},
  author={Ellen L O'Dea and Jeffrey D. Kearns and Alexander Hoffmann},
  journal={Molecular cell},
  year={2008},
  volume={30 5},
  pages={632-41}
}
Inflammatory activation of NF-kappaB involves the stimulus-induced degradation of the NF-kappaB-bound inhibitor IkappaB via the IkappaB kinase (IKK). In response to UV irradiation, however, the mechanism and function of NF-kappaB activation remain unclear. Using a combined biochemical, genetic, and computational modeling approach, we delineate a dual requirement for constitutive IKK-dependent and IKK-independent IkappaB degradation pathways in conjunction with UV-induced translational… CONTINUE READING