UV activates growth factor receptors via reactive oxygen intermediates

  title={UV activates growth factor receptors via reactive oxygen intermediates},
  author={Ruey-Song Huang and Jiangyue Wu and Yichao Fan and E. D. Adamson},
  journal={The Journal of Cell Biology},
  pages={211 - 220}
Exposure of mammalian cells to UV irradiation induces rapid and transient expression of early growth response-1 gene (Egr-1) encoding a transcription factor that plays a role in cell survival. These signals from the irradiated cell surface are likely to involve more than one pathway, and we show here that an essential pathway involves activation of several growth factor receptors by reactive oxygen intermediates (ROI). UVC irradiation causes the tyrosine phosphorylation of EGF receptor (EGFR… CONTINUE READING


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