UV-A irradiation induces a decrease in the mitochondrial respiratory activity of human NCTC 2544 keratinocytes.

@article{DjavaheriMergny2001UVAII,
  title={UV-A irradiation induces a decrease in the mitochondrial respiratory activity of human NCTC 2544 keratinocytes.},
  author={Mojgan Djavaheri-Mergny and C{\'e}cile Marsac and C{\'e}cile Mazi{\`e}re and Ren{\'e} Santus and L Michel and Louis Dubertret and Jean Claude Mazi{\`e}re},
  journal={Free radical research},
  year={2001},
  volume={34 6},
  pages={583-94}
}
UV-A irradiation caused a dose-dependent decrease in cellular oxygen consumption (56%) and ATP content (65%) in human NCTC 2544 keratinocytes, one hour after treatment. This effect was partially reversed by maintaining the irradiated cells in normal culture conditions for 24 h. Using malate/glutamate or succinate as substrates for mitochondrial electron transport, the oxygen uptake of digitonin-permeabilised cells was greatly inhibited following UV-A exposure. These results strongly suggest… CONTINUE READING