UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1.

@article{Choi2015UTXIE,
  title={UTX inhibits EMT-induced breast CSC properties by epigenetic repression of EMT genes in cooperation with LSD1 and HDAC1.},
  author={Hee-Joo Choi and Jihye Park and Mikyung Park and Hee-Young Won and Hyeong-Seok Joo and Chang Hoon Lee and Jeong-Yeon Lee and G K Kong},
  journal={EMBO reports},
  year={2015},
  volume={16 10},
  pages={1288-98}
}
The histone H3K27 demethylase, UTX, is a known component of the H3K4 methyltransferase MLL complex, but its functional association with H3K4 methylation in human cancers remains largely unknown. Here we demonstrate that UTX loss induces epithelial-mesenchymal transition (EMT)-mediated breast cancer stem cell (CSC) properties by increasing the expression of the SNAIL, ZEB1 and ZEB2 EMT transcription factors (EMT-TFs) and of the transcriptional repressor CDH1. UTX facilitates the epigenetic… CONTINUE READING
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