UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.

@article{Benyoucef2016UTXIA,
  title={UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia.},
  author={Aissa Benyoucef and C. G. Palii and Chaochen Wang and Christopher J Porter and Alphonse Chu and Fengtao Dai and V{\'e}ronique Tremblay and Patricia Rakopoulos and Kulwant Singh and Suming Huang and Francoise Pflumio and J. -L. Hebert and Jean-François Couture and Theodore J. Perkins and Kai Ge and F Jeffrey Dilworth and Marjorie Brand},
  journal={Genes & development},
  year={2016},
  volume={30 5},
  pages={508-21}
}
T-cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous group of hematological tumors composed of distinct subtypes that vary in their genetic abnormalities, gene expression signatures, and prognoses. However, it remains unclear whether T-ALL subtypes differ at the functional level, and, as such, T-ALL treatments are uniformly applied across subtypes, leading to variable responses between patients. Here we reveal the existence of a subtype-specific epigenetic vulnerability in T-ALL by… CONTINUE READING

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