UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

@article{Agger2007UTXAJ,
  title={UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development},
  author={Karl Agger and Paul A. C. Cloos and Jesper Heile Christensen and Diego Pasini and Simon Rose and Juri Rappsilber and Irina Issaeva and Eli Canaani and Anna Elisabetta Salcini and Kristian Helin},
  journal={Nature},
  year={2007},
  volume={449},
  pages={731-734}
}
The trithorax and the polycomb group proteins are chromatin modifiers, which play a key role in the epigenetic regulation of development, differentiation and maintenance of cell fates. The polycomb repressive complex 2 (PRC2) mediates transcriptional repression by catalysing the di- and tri-methylation of Lys 27 on histone H3 (H3K27me2/me3). Owing to the essential role of the PRC2 complex in repressing a large number of genes involved in somatic processes, the H3K27me3 mark is associated with… Expand
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