UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development

  title={UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development},
  author={Karl Agger and Paul A. C. Cloos and Jesper Heile Christensen and Diego Pasini and Simon Rose and Juri Rappsilber and Irina Issaeva and Eli Canaani and Anna Elisabetta Salcini and Kristian Helin},
The trithorax and the polycomb group proteins are chromatin modifiers, which play a key role in the epigenetic regulation of development, differentiation and maintenance of cell fates. The polycomb repressive complex 2 (PRC2) mediates transcriptional repression by catalysing the di- and tri-methylation of Lys 27 on histone H3 (H3K27me2/me3). Owing to the essential role of the PRC2 complex in repressing a large number of genes involved in somatic processes, the H3K27me3 mark is associated with… 

The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.

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Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.

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KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation

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Polycomb Repressive Complex 2 and H3K27me3 Cooperate with H3K9 Methylation To Maintain Heterochromatin Protein 1α at Chromatin

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Histone Methylases and Demethylases Regulating Antagonistic Methyl Marks: Changes Occurring in Cancer

A picture is emerging which indicates that the changes which occur in cancer during methylation of histone lysines can lead to repression of genes, including tumour suppressor genes, or to the activation of oncogenes.

Histone Demethylase Activity of Utx Is Essential for Viability and Regulation of HOX Gene Expression in Drosophila

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Stage-Dependent and Locus-Specific Role of Histone Demethylase Jumonji D3 (JMJD3) in the Embryonic Stages of Lung Development

Findings demonstrate that Jmjd3 plays a stage-dependent and locus-specific role in the mouse lung development, and provides molecular insights into the mechanisms by which JmJd3 regulates target gene expression in the embryonic stages of lung development.



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Genome-wide mapping of Polycomb target genes unravels their roles in cell fate transitions.

The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Here, we identify their

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