UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.

@article{Lee2012UTXAH,
  title={UTX, a histone H3-lysine 27 demethylase, acts as a critical switch to activate the cardiac developmental program.},
  author={Seunghee Lee and Jae Woon Lee and Soo-Kyung Lee},
  journal={Developmental cell},
  year={2012},
  volume={22 1},
  pages={25-37}
}
The removal of histone H3 lysine27 (H3K27) trimethylation mark is important for the robust induction of many cell type-specific genes during differentiation. Here we show that UTX, a H3K27 demethylase, acts as a critical switch to promote a cardiac-specific gene program. UTX-deficient ESCs failed to develop heart-like rhythmic contractions under a cardiac… CONTINUE READING