UTRme: A Scoring-Based Tool to Annotate Untranslated Regions in Trypanosomatid Genomes
@article{Rado2018UTRmeAS, title={UTRme: A Scoring-Based Tool to Annotate Untranslated Regions in Trypanosomatid Genomes}, author={Santiago Rad{\'i}o and R. Fort and B. Garat and J. Sotelo-Silveira and Pablo Smircich}, journal={Frontiers in Genetics}, year={2018}, volume={9} }
Most signals involved in post-transcriptional regulatory networks are located in the untranslated regions (UTRs) of the mRNAs. Therefore, to deepen our understanding of gene expression regulation, delimitation of these regions with high accuracy is needed. The trypanosomatid lineage includes a variety of parasitic protozoans causing a significant worldwide burden on human health. Given their peculiar mechanisms of gene expression, these organisms depend on post-transcriptional regulation as the… CONTINUE READING
Figures, Tables, and Topics from this paper
6 Citations
Upstream ORFs Influence Translation Efficiency in the Parasite Trypanosoma cruzi
- Biology, Medicine
- Frontiers in Genetics
- 2020
- 1
- PDF
SLFinder, a pipeline for the novel identification of splice-leader sequences: a good enough solution for a complex problem
- Computer Science, Medicine
- BMC Bioinformatics
- 2020
- 1
Conserved motifs in nuclear genes encoding predicted mitochondrial proteins in Trypanosoma cruzi
- Medicine, Biology
- PloS one
- 2019
- 1
- PDF
Aligning Protein-Coding Nucleotide Sequences with MACSE.
- Computer Science, Medicine
- Methods in molecular biology
- 2021
EIF2α phosphorylation is regulated in intracellular amastigotes for the generation of infective Trypanosoma cruzi trypomastigote forms
- Biology, Medicine
- Cellular microbiology
- 2020
References
SHOWING 1-10 OF 51 REFERENCES
Global estimation of the 3' untranslated region landscape using RNA sequencing.
- Biology, Medicine
- Methods
- 2015
- 28
Genome-wide analysis of 3′-untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes
- Biology, Medicine
- PeerJ
- 2013
- 23
- PDF
Dynamic analyses of alternative polyadenylation from RNA-seq reveal a 3'-UTR landscape across seven tumour types.
- Biology, Medicine
- Nature communications
- 2014
- 222
- PDF
Comparative ribosome profiling reveals extensive translational complexity in different Trypanosoma brucei life cycle stages
- Biology, Medicine
- Nucleic acids research
- 2014
- 114
Implication of CA repeated tracts on post-transcriptional regulation in Trypanosoma cruzi.
- Biology, Medicine
- Experimental parasitology
- 2013
- 6
Roar: detecting alternative polyadenylation with standard mRNA sequencing libraries
- Computer Science, Biology
- BMC Bioinformatics
- 2016
- 28
TcUBP-1, a Developmentally Regulated U-rich RNA-binding Protein Involved in Selective mRNA Destabilization in Trypanosomes*
- Biology, Medicine
- The Journal of Biological Chemistry
- 2001
- 83
- PDF
TcTASV: A Novel Protein Family in Trypanosoma cruzi Identified from a Subtractive Trypomastigote cDNA Library
- Biology, Medicine
- PLoS neglected tropical diseases
- 2010
- 17
- PDF
Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi
- Biology, Medicine
- BMC Genomics
- 2015
- 77