USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.

@article{Durcan2014USP8RM,
  title={USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin.},
  author={Thomas M. Durcan and Matthew Y. Tang and Jo{\"e}lle R. P{\'e}russe and Eman A Dashti and Miguel A Aguileta and Gian-Luca McLelland and Priti Gros and Thomas A. Shaler and Denis Faubert and Benoit Coulombe and Edward A. Fon},
  journal={The EMBO journal},
  year={2014},
  volume={33 21},
  pages={2473-91}
}
Mutations in the Park2 gene, encoding the E3 ubiquitin-ligase parkin, are responsible for a familial form of Parkinson's disease (PD). Parkin-mediated ubiquitination is critical for the efficient elimination of depolarized dysfunctional mitochondria by autophagy (mitophagy). As damaged mitochondria are a major source of toxic reactive oxygen species within the cell, this pathway is believed to be highly relevant to the pathogenesis of PD. Little is known about how parkin-mediated ubiquitination… CONTINUE READING
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