USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin

  title={USP7 counteracts SCFβTrCP- but not APCCdh1-mediated proteolysis of Claspin},
  author={Helene Faustrup and Simon Bekker-Jensen and Jiri Bartek and Jiri Lukas and Niels Mailand},
  journal={The Journal of Cell Biology},
  pages={13 - 19}
Claspin is an adaptor protein that facilitates the ataxia telangiectasia and Rad3-related (ATR)-mediated phosphorylation and activation of Chk1, a key effector kinase in the DNA damage response. Efficient termination of Chk1 signaling in mitosis and during checkpoint recovery requires SCF(betaTrCP)-dependent destruction of Claspin. Here, we identify the deubiquitylating enzyme ubiquitin-specific protease 7 (USP7) as a novel regulator of Claspin stability. Claspin and USP7 interact in vivo, and… CONTINUE READING


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