USP48 restrains resection by site-specific cleavage of the BRCA1 ubiquitin mark from H2A

Abstract

BRCA1-BARD1-catalyzed ubiquitination of histone H2A is an important regulator of the DNA damage response, priming chromatin for repair by homologous recombination. However, no specific deubiquitinating enzymes (DUBs) are known to antagonize this function. Here we identify ubiquitin specific protease-48 (USP48) as a H2A DUB, specific for the C-terminal BRCA1… (More)
DOI: 10.1038/s41467-017-02653-3

4 Figures and Tables

Topics

  • Presentations referencing similar topics