USP47 and C Terminus of Hsp70-Interacting Protein (CHIP) Antagonistically Regulate Katanin-p60-Mediated Axonal Growth

@article{Yang2013USP47AC,
  title={USP47 and C Terminus of Hsp70-Interacting Protein (CHIP) Antagonistically Regulate Katanin-p60-Mediated Axonal Growth},
  author={Seung Wook Yang and Kyu Hee Oh and Esther Park and Hyun Min Chang and Jung Mi Park and Min Woo Seong and Seung Hyeun Ka and Woo Keun Song and Dong Eun Park and Peter W. Baas and Young Joo Jeon and Chin Ha Chung},
  journal={The Journal of Neuroscience},
  year={2013},
  volume={33},
  pages={12728 - 12738}
}
Katanin is a heterodimeric enzyme that severs and disassembles microtubules. While the p60 subunit has the enzyme activity, the p80 subunit regulates the p60 activity. The microtubule-severing activity of katanin plays an essential role in axonal growth. However, the mechanisms by which neuronal cells regulate the expression of katanin-p60 remains unknown. Here we showed that USP47 and C terminus of Hsp70-interacting protein (CHIP) antagonistically regulate the stability of katanin-p60 and… Expand
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