USP4 Auto-Deubiquitylation Promotes Homologous Recombination.

@article{Wijnhoven2015USP4AP,
  title={USP4 Auto-Deubiquitylation Promotes Homologous Recombination.},
  author={Paul W G Wijnhoven and Rebecca Konietzny and Andrew N Blackford and Jonathan Travers and Benedikt M. Kessler and Ryotaro Nishi and Stephen P. Jackson},
  journal={Molecular cell},
  year={2015},
  volume={60 3},
  pages={362-73}
}
Repair of DNA double-strand breaks is crucial for maintaining genome integrity and is governed by post-translational modifications such as protein ubiquitylation. Here, we establish that the deubiquitylating enzyme USP4 promotes DNA-end resection and DNA repair by homologous recombination. We also report that USP4 interacts with CtIP and the MRE11-RAD50-NBS1 (MRN) complex and is required for CtIP recruitment to DNA damage sites. Furthermore, we show that USP4 is ubiquitylated on multiple sites… CONTINUE READING
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