USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase

@inproceedings{Fan2014USP21NR,
  title={USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase},
  author={Yihui Fan and Renfang Mao and Yang Yu and Shangfeng Liu and Zhongcheng Shi and Jin Cheng and Huiyuan Zhang and Lei An and Yanling Zhao and Xin Xu and Zhenghu Chen and Mari Kogiso and Dekai Zhang and Hong Zhang and Pumin Zhang and Jae U Jung and Xiaonan Li and Guotong Xu and Jianhua Yang},
  booktitle={The Journal of experimental medicine},
  year={2014}
}
Lys63-linked polyubiquitination of RIG-I is essential in antiviral immune defense, yet the molecular mechanism that negatively regulates this critical step is poorly understood. Here, we report that USP21 acts as a novel negative regulator in antiviral responses through its ability to bind to and deubiquitinate RIG-I. Overexpression of USP21 inhibited RNA virus-induced RIG-I polyubiquitination and RIG-I-mediated interferon (IFN) signaling, whereas deletion of USP21 resulted in elevated RIG-I… CONTINUE READING

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