USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency

@inproceedings{Liu2016USP21DN,
  title={USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency},
  author={Xingyu Liu and Yuying Yao and Hui Ding and Chuanchun Han and Yuhan Chen and Yuan Zhang and Chanjuan Wang and Xin Zhang and Yiling Zhang and Yun Zhai and Ping Wang and Wenyi Wei and Jing Zhang and Lingqiang Zhang},
  booktitle={Signal Transduction and Targeted Therapy},
  year={2016}
}
The homeobox transcription factor Nanog has a vital role in maintaining pluripotency and self-renewal of embryonic stem cells (ESCs). Stabilization of Nanog proteins is essential for ESCs. The ubiquitin–proteasome pathway mediated by E3 ubiquitin ligases and deubiquitylases is one of the key ways to regulate protein levels and functions. Although ubiquitylation of Nanog catalyzed by the ligase FBXW8 has been demonstrated, the deubiquitylase that maintains the protein levels of Nanog in ESCs yet… CONTINUE READING

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References

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BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.

Proceedings of the National Academy of Sciences of the United States of America • 2015

The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.

Proceedings of the National Academy of Sciences of the United States of America • 2015

Deubiquitination and stabilization of IL-33 by USP21.

International journal of clinical and experimental pathology • 2014

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