USP15 is a deubiquitylating enzyme for receptor-activated SMADs

@article{Inui2011USP15IA,
  title={USP15 is a deubiquitylating enzyme for receptor-activated SMADs},
  author={Masafumi Inui and Andrea Manfrin and Anant Mamidi and Graziano Martello and Leonardo Morsut and Sandra Soligo and Elena Enzo and Stefano Moro and Simona Polo and Sirio Dupont and Michelangelo Cordenonsi and Stefano Lo Piccolo},
  journal={Nature Cell Biology},
  year={2011},
  volume={13},
  pages={1368-1375}
}
The TGFβ pathway is critical for embryonic development and adult tissue homeostasis. On ligand stimulation, TGFβ and BMP receptors phosphorylate receptor-activated SMADs (R-SMADs), which then associate with SMAD4 to form a transcriptional complex that regulates gene expression through specific DNA recognition. Several ubiquitin ligases serve as inhibitors of R-SMADs, yet no deubiquitylating enzyme (DUB) for these molecules has so far been identified. This has left unexplored the possibility… CONTINUE READING

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