USP11 regulates p53 stability by deubiquitinating p53

  title={USP11 regulates p53 stability by deubiquitinating p53},
  author={Jia-ying Ke and Cong-jie Dai and Wen-lin Wu and Jin-hua Gao and Ai-juan Xia and Guang-ping Liu and Kao-sheng Lv and Chun-lin Wu},
  journal={Journal of Zhejiang University SCIENCE B},
The p53 tumor suppressor protein coordinates the cellular responses to a broad range of cellular stresses, leading to DNA repair, cell cycle arrest or apoptosis. The stability of p53 is essential for its tumor suppressor function, which is tightly controlled by ubiquitin-dependent degradation primarily through its negative regulator murine double minute 2 (Mdm2). To better understand the regulation of p53, we tested the interaction between p53 and USP11 using co-immunoprecipitation. The results… CONTINUE READING
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